Abstract
Objective To study the correlation between knee biomechanics and clinical manifestation in adults with Kaschin-Beck disease (KBD). Methods Three hundred and eighty-nine digital radiographic X-ray (DR) anteroposterior keen films of adult KBD patients diagnosed at the Center for Disease Control and Prevention of Gansu Province from Sep 2012 to Sep 2016 were taken as subjects of observation and were retrospectively reviewed. Every patient must undergo a WOMAC function evaluation for knee joint and biomechanic angle measure for the lower limbs on the DR film which included femur angle, tibial angle, femur-tibial angle and joint space angle, Insall-Salvati index(LT/LP), and LT/HI index. Then, the regression equation was built and the correlation analysis was made with multiple linear regression test. Results Three hundred and eighty-nine patients' average scores of femur angle (X1), tibial angle (X2), joint space angle (X3), femur-tibial angle (X4), LT/LP index (X5), LT/HI index (X6) and WOMAC evaluation were (76.32 ± 2.05)°, (110.65 ± 4.68)°, (4.73 ± 0.91)°, (137.56 ± 2.29)°, 0.98 ± 0.12, 1.73 ± 0.11, and (61.35 ± 7.68) scores. By multiple linear regression test, femur angle, tibial angle, femur-tibial angle, LT/LP index, and LT/HI index were selected to enter into the equation; while, joint space angle was rejected. The multiple linear regression equation was as follows: Y=-77.307-6.327X6 + 1.360X1 + 1.310X5 + 0.331X4-0.147X2. The adjusted determination coefficient(R2) of the equation was 0.958. Through variance analysis, the fitted equation had statistical significance (F = 1 790.391, P < 0.05). Through two-tailed significance test, the above-mentioned 5 indexes that were adopted to enter this question were in significant correlation with WOMAC scores (P < 0.05). Conclusion There is a significant correlation between knee biomechanic angle and WOMAC scoring in adults with KBD, which is reflected with the following parameters from big to small in turn: femur angle, tibial angle, LT/LP index, femur-tibial angle, LT/HI index. Key words: Kashin-Beck disease, Biomechanics; X-ray; WOMAC score; Regression analysis
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