Abstract
Objective: The purposes of this research were the antihyperglycemic and antioxidant determination of klutuk banana peel fractions through the oral glucose tolerance test (OGTT) and DPPH (2,2-diphenyl-1-picrylhydrazyl) methods, respectively.
 Methods: Klutuk banana peel was extracted by reflux method and followed by fractionation using n-hexane and ethyl acetate solvents by liquid-liquid extraction method. The statistical analysis used by one-way ANOVA and post hoc Tukey.
 Results: The results of OGTT showed that ethyl acetate fraction of klutuk banana peel 14.5 mg/kg bw demonstrated higher activity to decrease blood glucose level compared to the other groups as much-32%,-49%,-47% and-40% at min 30, 60, 90 and 120, respectively. The IC50 of ethyl acetate fraction of klutuk banana peel was 0.3708 µg/ml, and its antioxidant activity index (AAI) 40.45.
 Conclusion: The ethyl acetate fraction of klutuk peel presented very strong antioxidant and antihyperglycemic activity.
Highlights
The most prevalent endocrine condition arising from a defect in insulin secretion, insulin tolerance or a mixture of these is diabetes mellitus (DM) [1]
The identification results showed that the samples used were true klutuk banana plants (Musa balbisiana Colla)
The results presented that the n-hexane, ethanol extract, ethyl acetate, water fractions of klutuk banana (Musa balbisiana Colla) peels and vitamin C had the ability to scavenge DPPH free radicals
Summary
The most prevalent endocrine condition arising from a defect in insulin secretion, insulin tolerance or a mixture of these is diabetes mellitus (DM) [1]. Banana is considered one of the most essential foods abundant in antioxidants [5]. Banana is widely eaten by many individuals and the composition of bioactive compounds has important antioxidant activities that have been beneficial in holding the body against different oxidative stress [6]. Normally discarded, is a decent source of dietary fiber and bioactive compounds [7]. Many experiments have recorded high levels of essential bioactive compounds in banana peel than pulp that could be used as a functional source of food against many chronic diseases like diabetes mellitus [5, 8,9,10]. Further research was needed to discover and apply dietary fiber and natural antioxidants that contained in banana peel for health benefits. We conducted the antioxidant and antihyperglycemic activity of the fractions of n-hexane, ethyl acetate and water extracts from the peel of klutuk banana (Musa balbisiana Colla)
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