Klotho, a protective renal factor for platelet lifespan

Abstract

Chronic kidney disease (CKD) is a progressive condition characterized by kidney damage or reduced kidney function and is categorized into five stages based on the Kidney Disease Outcomes Quality Initiative guidelines. Owing to the lack of an effective cure and high morbidity and mortality in the general adult population, CKD will become the fifth leading cause of death globally by 2040.1 Usually, CKD is considered a hypercoagulable state associated with a high prevalence of arterial and venous thromboembolisms, which have become the main causes of mortality in these patients.