Abstract
Background: The differential diagnosis of reactive mesothelium (RM) from malignant pleural mesothelioma (MPM) can be a major challenge. A number of markers have been proposed, including EMA, GLUT-1, IMP3, p53 protein, and P-glycoprotein, however, up to present, there exists no immunohistochemical (IHC) marker which confidently allows for the separation of RM and MPM. Klotho is originally discovered as an anti-aging gene and identified as a tumor suppressor in various cancers. Recent studies have demonstrated aberrant expression of Klotho in a number of cancers, including lung cancer. Klotho was shown to suppress the epithelial-mesenchymal transition. The purpose of the present study was to evaluate the diagnostic utility of Klotho expression in the differential diagnosis between MPM and RM.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
