KLINICZNE ZNACZENIE WYBRANYCH POLIMORFI ZMÓW GENU MDR1 U CHORYCH NA RAKA JELITA GRUBEGO

Abstract

Colorectal cancer is one of the most common malignancies. It is the second most common cause of cancer death in men and the third most common in women. The aetiology of colorectal cancer is multifactorial, complicated, and remains the subject of many studies. It has been estimated that only 15-30% cases of colorectal cancer are hereditary. The aim of the study was to determine the relationship between the C3435T and G2677T/A polymorphisms of the MDR1 gene and the risk of developing colorectal cancer. The study group comprised 47 women and 60 men with colorectal cancer. The age of patients was 47-83 years. In each case the diagnosis of colorectal cancer was confirmed by histopathological examination. The control group comprised 110 subjects without malignant colorectal cancer. Genetic analysis was carried out using PCR-RFLP. A relationship between the presence of CT and TT genotypes of C3435T MDR1 gene polymorphism and onset of colorectal cancer at a younger age was found. No correlation between C3435T or G2677T/A MDR1 gene polymorphism and other clinical parameters was identified. Further studies are necessary on a significantly greater number of genes and their polymorphisms. Findings from this study may be used as a part of polygenic analysis aimed at explaining the complicated processes responsible for the onset and development of colorectal cancer.