Abstract
Kleine-Levin syndrome (KLS) is a neuropsychiatric sleep disorder primarily affecting adolescent males. Onset is insidious, idiopathic, and hastened by neurological incident or infection. Typically, the initial onset occurs during the teen years or after the second decade, although cases have been documented in early childhood, adulthood, and senescence. KLS is marked by unexpected debilitating, yet reversible, episodic hypersomnia, with varying recurrence rates; cognitive and behavioral impairment; compulsive eating; and feelings of derealization, hypersexuality, apathy, and depressed mood. Diagnosis is problematic due to the syndrome's rarity, disparity of presenting clinical symptoms, and misdiagnosis. Correct diagnosis can take up to 4 years. The clinical course is approximately 8 to 14 years from initial onset, yet may be longer in the adult form of the disorder. KLS has been shown to impact activities of daily living, usurping an adolescent of his/her social relations with peers, experiences, and time.
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