Abstract
BackgroundThe objective of the study was to detect the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC-1) in gastric cancer (GC) specimens and analyse the associations between KK-LC-1 expression and clinicopathological parameters and clinical prognosis.MethodsAll of the 94 patients in this study were GC patients who underwent surgical resection. KK-LC-1 protein expression in GC tissue was detected by immunohistochemistry. This report applies the histological score (H-score) to evaluate KK-LC-1 expression. To calculate this indicator, the number of positive cells in each section and their staining intensity were converted to corresponding values. The expression of KK-LC-1 in the cytoplasm of cancer and normal tissues was scored to obtain their respective H values. The chi-square test, Kaplan-Meier method and Cox regression were used to analyse the linear association between KK-LC-1 expression and clinicopathological data and prognosis.ResultsIn the cytoplasm, KK-LC-1 expression in tumour tissues was significantly higher than that in normal tissues (P < 0.001). Using the median H-score as the cut-off value, we discovered that GC patients with high levels of KK-LC-1 expression in the cytoplasm had favourable overall survival (OS) (P = 0.016), and this result was statistically significant in the Cox regression analysis. Additionally, a negative correlation was found between KK-LC-1 protein expression and the pathological grade of the tumour (P = 0.036), with significantly more KK-LC-1 protein expression observed in the intestinal type of GC than in the diffuse type (P = 0.008).ConclusionsOur research data showed that KK-LC-1 expression was greater in GC tissues than in normal tissues, and higher KK-LC-1 expression was associated with longer OS of GC patients. KK-LC-1 can be used as a biomarker for a good prognosis in GC patients.
Highlights
The objective of the study was to detect the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC1) in gastric cancer (GC) specimens and analyse the associations between KK-LC-1 expression and clinicopathological parameters and clinical prognosis
We observed that KK-LC-1 expression was higher in tumour tissues than in normal tissues (P < 0.001)
Akiko et al found that the gene expression rate of KK-LC-1 reached 81.6%, which was significantly higher than that found in other studies [23]
Summary
The objective of the study was to detect the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC1) in gastric cancer (GC) specimens and analyse the associations between KK-LC-1 expression and clinicopathological parameters and clinical prognosis. Various molecular biomarkers are efficient diagnostic and prognostic tools for gastric cancer, but these biomarkers need further validation before they can be used in daily clinical practice. The only biomarkers used for GC are carcinoembryonic antigens CA 19–9, CA-50 [4] and CA-72 [5]. These are limited by insufficient sensitivity and specificity to evaluate GC diagnosis and prognosis, and the efficacy of targeting these biomarkers for clinical treatment is doubtful
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