Abstract
BackgroundSecondary hypertension accounts for 5% of all cases of hypertension. Renal artery stenosis is one of the common causes of secondary hypertension. Atherosclerosis and fibromuscular dysplasia are the commonest types of stenosis associated with renal vascular hypertension, with the former accounting for 70–80% of all cases and the latter accounting for 10% of the incidence. The greatest incidence atherosclerosis is in men over the age of 40 years, mostly affecting the proximal part of the renal arteries, whereas fibromuscular dysplasia affects women ranging in age from 30 to 50 years. Currently, possible treatments are medical treatment using blood pressure-lowering drugs, balloon angioplasty with or without stent insertion, and surgery to reconstruct the artery.Case presentationWe report a case of a 46-year-old Asian woman with stenosis of two branches of renal artery bifurcation treated by percutaneous balloon dilatation and stenting of both branches after referral to our department for a renal angiogram following 8 months of uncontrolled hypertension despite receiving medications. Initially, the patient presented with severe headache and fatigue. She was a known nonsmoker, was not diabetic, and had no history of diabetes in her family. She had no history of atherosclerosis. Apart from high blood pressure, the result of her physical examination was unremarkable. Laboratory investigations revealed normal serum cholesterol, lipid profile, and serum creatinine. She had been attending a hypertension clinic and receiving antihypertensive drugs for the past 8 months on a regular basis under close observation. Despite this treatment and care, her blood pressure remained high at 175/110 mmHg, which the attending doctor concluded to be uncontrolled blood pressure. Initial imaging indicated left renal artery stenosis, and the patient was referred to our department.ConclusionsFor patients with uncontrolled hypertension despite receiving medications, renal Doppler ultrasound should be included in the diagnostic workup for secondary hypertension. Once renal artery stenosis is suspected, renal angiography is highly recommended because the technique is able to accurately diagnose stenosis in the branch arteries, unlike computed tomographic angiography and magnetic resonance angiography. Percutaneous transluminal renal angioplasty is the treatment of choice for renal artery stenosis in patients with renovascular hypertension or renal dysfunction.
Highlights
Secondary hypertension accounts for 5% of all cases of hypertension
Atherosclerosis and fibromuscular dysplasia are the commonest types of stenosis associated with renal vascular hypertension (RVH)
The greatest incidence is in men over the age of 40 years, mostly affecting the proximal part of the renal arteries [4] .Unlike Atherosclerotic renal artery stenosis (ARAS), renal artery fibromuscular dysplasia (RAFMD) affects women ranging in age from 30 to 50 years; among patients with RVH, the incidence of RAFMD is about 10%
Summary
Secondary hypertension accounts for 5% of all cases of hypertension. Renal artery stenosis is one of the common causes of secondary hypertension. Atherosclerosis and fibromuscular dysplasia are the commonest types of stenosis associated with renal vascular hypertension, with the former accounting for 70–80% of all cases and the latter accounting for 10% of the incidence. Laboratory investigations revealed normal serum cholesterol, lipid profile, and serum creatinine She had been attending a hypertension clinic and receiving antihypertensive drugs for the past 8 months on a regular basis under close observation. Atherosclerosis and fibromuscular dysplasia are the commonest types of stenosis associated with renal vascular hypertension (RVH). Percutaneous transluminal balloon angioplasty is an accepted treatment for selected cases of renal artery stenosis caused by fibromuscular dysplasia [3], and stenting is the primary endovascular means for the treatment of ARAS, with technical success rates for renal artery stent placement approaching 95% [6]
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