Abstract
Kissing or Fused Since Some Time
Highlights
Exocytosis was originally proposed to support the brevity of presynaptic transmitter output that account for postsynaptic transient responses
If the opening of the pore is not sufficient for fast release, and if another mechanism needs to expel the transmitter wherever it comes from, why the opening of a vesicle would necessarily precede immediately each release? There is no direct evidence either that the transmitter is released from the vesicular lumen or that release happens just after the pore opens
Evidence was provided that the transmitter can be held under a nondiffusible form in the matrix of presynaptic vesicles (Reigada et al, 2003) and that it can be held by the synaptomatrix at the presynaptic surface (Vautrin et al, 2000)
Summary
Exocytosis was originally proposed to support the brevity of presynaptic transmitter output that account for postsynaptic transient responses. Fast freezing electron microscopy and membrane labeling techniques demonstrated that exocytosis is involved in presynaptic activity, the opening of the vesicular lumen is automatically assumed to be the mechanism that releases the transmitter.
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