KISS-1 peptine and its receptor GPR54 placental expression in early and late-onset preeclampsia

Abstract

Background Fail of trophoblastic invasion that is followed by abnormal placental development is thought to be one of the basic pathogenic pathways of preeclampsia (PE). Objective To study KISS-1 and its receptor GPR54 placental expression in early and late-onset PE. Materials and methods All the placentas from PE complicated pregnancies were divided into 2 groups: early-onset PE (11 cases) and late-onset (18 cases). Both groups were also subdivided into moderate and severe PE subgroups. Control group included 12 placentas from uncomplicated pregnancies. Immunohistochemistry with KISS-1 and GPR54 antibodies was performed. Results Both KISS-1 and GPR54 placental syncytial and endothelial expression levels were significantly elevated in severe early-onset PE subgroup compared to control ( p p Conclusion The study revealed KISS-1 and GPR54 placental expression patterns showed different pathogenic pathways of early and late-onset PE.