Abstract
Mussels (Mytilus galloprovincialis) are aquatic organisms that can accumulate all the factors that pollute the fresh and saltwater environment. Although the Dardanelles has been exposed to environmental pollution for many years, it is also an important region for crustaceans. We aimed to investigate the histopathological changes in the liver parenchyma which is an important gland of the digestive system by feeding these mussels to rats. Twenty-four male Wistar albino were used in the study. The first group (control): fed with standard rat feed, the second group (experiment 1): 4/5 mussel + 1/5 standard rat feed daily; third group (experiment 2): 4/5 mussel + 1/5 standard rat feed every other day, the fourth group (experiment 3): groups were formed with 4/5 mussel + 1/5 standard rat feed every three days. All liver tissue samples taken from the experimental and control groups were stained with hematoxylin-eosin, and immuohitochemically staining inflammatory marker TNF-α and NF-κB after routine histopathological follow-up and analyzed with a light microscope image analysis system. It was observed that mononuclear cells caused inflammation of portal areas, increased sinusoidal dilatation and congestion and degeneration due to vacuolization in hepatocytes in the liver parenchyma of mussel-fed rats. Besides, immunohistochemical staining, TNF-α, and NF-κB immunoreactivity were observed in the liver cells of especially in the second group of rats. As a result, it has been shown that the consumption of mussels obtained and marketed without considering environmental pollution may trigger important digestive system organs of liver diseases.
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