Abstract
Background The membrane potential of striatal medium spiny neurons (MSNs) fluctuates between downand up-states. In ventral striatum, inward rectifying potassium (KIR) currents in 40% of MSNs inactivate [1]. KIR current inactivation appears to alter spike frequency and onset during upstates [2]. However, it is not known whether these translate into significant changes in calcium dynamics in the dendrites. We describe a computational study investigating how this inactivation influences dendritic calcium transients.
Highlights
The membrane potential of striatal medium spiny neurons (MSNs) fluctuates between down- and up-states
It was observed that dendritic calcium transients were significantly enhanced by KIR current inactivation (Figure 1)
InKIR cell when compared with non-inKIR cell had dendritic calcium transient peaks higher by as much as 93% in response to an injected current of 0.25 nA in the distal dendrite (Figure 1A)
Summary
The membrane potential of striatal medium spiny neurons (MSNs) fluctuates between down- and up-states. Inward rectifying potassium (KIR) currents in 40% of MSNs inactivate [1]. KIR current inactivation appears to alter spike frequency and onset during upstates [2]. It is not known whether these translate into significant changes in calcium dynamics in the dendrites. We describe a computational study investigating how this inactivation influences dendritic calcium transients
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