Kinin formation in human blood serum induced by cooling and by heat-aggregated human gamma globulin preparations, HAHGG

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The original kinin research at the Middlesex Hospital Medical School concerned, for many years, the occurrence of plasma kinin when the human plasma touched foreign surface such as glass (Armstrong et al, 1952, 1957; Keele & Armstrong, 1964; Armstrong, 1968a). More recently the work has centered upon the spontaneous occurrence of kinins when the human plasma (heparinized or citrated) or serum is cooled, e.g. 370 – 00 C, without contact with glass (Armstrong & Mills, 1965; Armstrong et al, 1967; Armstrong, 1968a,c). Although not all kinins are pa in-producing (see Armstrong, 1968a,c) the kinin produced by cooling of the human serum is, and in this it resembles the kinin induced by glass exposure of the serum. Both the kinin formation induced by glass and that induced by the cold exposure of serum are Hageman Factor dependent reactions (Margolis, 1957, 1958a,b, 1960; Armstrong, 1968c; see also Armstrong et al, 1967; Armstrong, 1968a,b and 1969a). They thus resemble one another and also the kinin formation induced by antigen-antibody precipitates (Movat, 1967; Movat et al, 1968; Boreham & Goodwin, 1969) which appears to be a Hageman Factor dependent reaction also.