Abstract
The mechanism of inhibition of the α-chymotrypsin enzyme by two lignans of the fused bistetrahydrofuran series, epiexcelsin (1) and 5′-demethoxyepiexcelsin (2), which were isolated from the Commiphora mukul Engl., was investigated. Lineweaver–Burk and Dixon plots and their secondary replots showed that these compounds were noncompetitive inhibitors of the enzyme. K i values for 1 and 2 were found to be 22.29 ± 0.015 and 336.30 ± 0.053 μM, respectively.
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