Abstract
Uptake of 3H-acetyl human growth hormone ( 3H-HGH) and 3H-acetyl bovine growth hormone ( 3H-BGH) into slices of hypophysectomized rat liver and human liver (obtained from autopsy) has been measured both as a function of time and concentration of the labeled hormones in the incubation medium. Uptake kinetics as a function of concentration of 3H-HGH or 3H-BGH in rat liver slices followed a sigmoid curve. Similar sigmoid curve was obtained when increasing concentrations of 3H-HGH were incubated with human liver slices. In contrast, uptake kinetics of 3H-BGH in human liver slices followed a hyperbolic curve. Addition of unlabeled HGH or BGH into the incubation medium reduced the uptake of 3H-HGH in rat liver slices but in human liver slices only human growth hormone competed. This binding-site difference along with the reported molecular differences between human and bovine growth hormones may well explain the different biological specificities of the two hormones.
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