Abstract
Abstract Ultrasound assisted extraction of wedelolactone, a major coumestan present in Eclipta alba, is investigated in the present work.Various process parameters such as type of solvent, power, solvent to solid ratio and extraction temperature, which affect the extraction yield, are optimized. In the ultrasound-assisted extraction with final optimized conditions, i.e., methanol as solvent, 170 W power, 60:1 solvent to solid ratio, 50 °C temperature and 60% duty cycle, amaximum extraction yieldof 0.62 mg/g is obtained in 45 minutes. The kinetic model (Peleg's model) has been used for the prediction of the yield of wedelolactone in the extract at a given time for all experimental conditions. The values of predicted yields show good agreement with the experimental data for all parameters, i.e., power, solvent to solid ratio and temperature. The extraction of wedelolactone from Eclipta alba is also carried out by conventional extraction methods, i.e., Soxhlet and batch extraction. Ultrasound-assisted extraction gives higher extraction yield in less time as compared to batch extraction (0.41 mg/g in 90 min) and Soxhlet extraction(0.7 mg/g in 360 min). The ultrasound-assisted extraction of wedelolactone from Eclipta alba is an effective way of extraction with the advantages of lower time and higher extraction.
Highlights
Eclipta alba is used in traditional herbal medicine worldwide
This is considered as the maximum obtainable yield, i.e., 100% extraction and used for comparison with the yield obtained by Ultrasound assisted extraction (UAE)
Extraction of wedelolactone from Eclipta alba leaves powder was successfully carried out using ultrasound
Summary
Eclipta alba is used in traditional herbal medicine worldwide. It is reported to possess anti-hyperglycemic, anti-hepatotoxic, antioxidant, anti-inflammatory, antifungal activities and a good hair growth regulator and potential memory modulator (Karthikumar et al, 2007; Wagner et al, 1986; Dalal et al, 2010). E. Alba is traditionally used to calm the mind, remove memory disorders, relieve swollen glands, strengthen the spleen, stimulate digestion, as a general tonic, for treatment of edema, fevers, rheumatic joint pains, liver damage due to cirrhosis, infective hepatitis, and hepatic enlargement, enlarged spleen and skin disorders. The major coumestan derivatives present in E. alba are wedelolactone and demethylwedelolactone. It possesses so many therapeutic activities, the extraction of wedelolactone has not been reported. The traditional solvent extraction technique used for extraction of natural products suffers from various disadvantages such as large solvent requirement, higher extraction time, lower yield and higher extraction temperature and requires development of an
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