Abstract
We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.
Highlights
We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests
Antibody response kinetics in patients with Middle East respiratory syndrome coronavirus (MERS-CoV) infection, by days after illness onset, as determined by using a 50% endpoint plaque reduction neutralization test (PRNT50) (A) and an S1 IgG ELISA (B)
An understanding of MERS-CoV antibody response kinetics helps in defining the window during which passive antibody therapy may be useful
Summary
We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. Antibody to MERS-CoV was detected by using the plaque reduction neutralization test (PRNT) and MERSCoV S1 IgG ELISA (EUROIMMUN, Lübeck, Germany) [4,5] (online Technical Appendix). Patient L, a 56-year-old woman with no underlying disease, had weakly positive PRNT50 (1:20) and borderline ELISA responses (optical density ratio 1.0), even at day 32 of illness.
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