Abstract
Irreversible protein aggregation resulting in formation and deposition of insoluble fibrils or amorphous precipitates is usually assumed to occur via sequential attachment of monomers to soluble intermediates. We complement this scheme by slow conversion of the intermediates to a relatively stable form so that they do not react with monomers but can be trapped by precipitates. For reasonable values of parameters, our model predicts that the aggregation kinetics order may be between 2.0 and 2.5. In particular, the model can be used to explain the reaction order, 2.17 +/- 0.09, observed for aggregation of recombinant human granulocyte colony stimulating factor.
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