Abstract
Equations giving plasma and urinary drug levels in terms of apparent first order absorption and elimination of drug, apparent volume of distribution of drug per kilogram, time, and release characteristics of sustained release preparations, are derived for the cases of oral administration of drug solution or a sustained release preparation. The equations are shown to describe the plasma levels obtained in dogs after administration of HT1479 (1-( o-methoxyphenyl)-4-(γ-methoxypropyl)-piperazine phosphate) as an oral solution or in sustained release tablets. The apparent first order constants for absorption and disappearance of drug from plasma were 2·0 hr −1 and 0·28 hr −1, respectively, and the release constants for the Gradumet tablet were similar to those obtained in vitro.
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