Kinetics of oxidation of glycylglycine by bromamine-T in acid medium

Abstract

The kinetics of oxidation of a typical dipeptide glycylglycine (GG) by bromamine-T have been studied in HClO4 medium at 40°C. The rate shows first-order dependence on [BAT]0 and is fractional order in [GG]0 which becomes independent of [substrate]0 at higher [GG]0. At [H+ ] > 0.02mol dm−3, the rate is inverse fractional in [H+ ] but is zero order at lower [H+ ] (≤0.02 mol dm−3). Variation in ionic strength or dielectric constant of the medium had no significant effect on the rate. The solvent-isotope effect was measured and\(k'_{H_2 O} /k'_{H_2 O} \)= 1.45. Proton inventory studies have been made. The reaction has been studied at different temperatures (308-323 K) and activation parameters have been computed.