Abstract
The inulin space of dog kidney slices obtained from cortex and outer and inner medulla was evaluated by incubating the tissue at different time intervals in inulin Ringer. When the kidney was cut normal to the major axis of Henle's loops and collecting ducts, inulin uptake appeared to follow a single exponential time function in each renal region.When the organ was cut parallel to the major axis of Henle's loops the inulin space was greater and inulin uptake appeared to follow two exponential functions of time in each of the three renal regions. This would indicate that the plane of section can influence the apparent size of the extracellular space of kidney slices, as measured by the distribution of inulin.
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