Abstract
Cells isolated from the hearts of newborn (1-day-old) rat accumulate <sup>14</sup>C-glucose. Insulin stimulates glucose accumulation by the heart cells. Values for net accumulation of glucose by heart cells agree well with those values obtained earlier using whole hearts. Lineweaver-Burk plots of initial rates of glucose accumulation at different concentrations of glucose show that the effect of insulin is to increase the V<sub>max</sub>. It is concluded that the effect of insulin is to increase the rate of glucose accumulation rather than to alter the concentration of glucose required to half-saturate the system. Glucose accumulation is also stimulated by mild trypsin digestion of the cells. Increasing concentrations of concanavalin A inhibit glucose accumulation.
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