Kinetics of hydrolase production by microorganisms

Abstract

ABSTRACT The enzyme-forming systems (EFSs) concerned with the amylase of Bacillus subtilis, and the glucamylase and acid protease of Aspergillus niger, have been shown to be highly stable in the cultural conditions applied owing to the low decay rate of mRNAs specific for these respective enzymes. The quantity per cell of mRNAs for any of these enzymes is regarded as limiting the specific rate of enzyme production in the conditions used for enzyme production. Investigations on the repression, derepression and the preferential synthesis of these hydrolases have led to simple hypothetical relationships.