Abstract
We explored the kinetics of CCR7 expression on T H1 and T H2 polarized cells as well as on antigen-specific T cell lines at various stages of differentiation. A striking pattern of early (days 7–14) inducible CCR7 expression was seen preferentially on primary T H1 cell lines, as compared to T H2 cells, and was dependent on the strength and duration of the T cell receptor signal. Upon repeated restimulation (days 21–28) and differentiation, a switch occurred in which T H2 cells had high CCR7 expression, whereas T H1 cells lost CCR7 expression. Chronic (8 weeks and later) effector memory cell lines were 95% CCR7 negative. These data demonstrate an ordered pattern of CCR7 expression that suggest more rapid priming of T H1 cells in the lymph node, and delayed priming with prolonged CCR7 expression during T H2 responses, and may have implications for tracking T H1 effector T cells ex vivo in autoimmune diseases.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
