Abstract
Stopped-flow kinetic measurements were carried out for the aggregation of acidic phospholipid vesicles induced by the addition of BeSO4solution. The phospholipid species examined were dimyristoylphosphatidic acid (DMPA), dimyristoylphosphatidylglycerol (DMPG), and dimyristoylphosphatidylserine (DMPS). For all of these phospholipid vesicles, BeSO4induced a rapid aggregation at extremely low concentration compared with other alkaline-earth metal salts. By increasing the solution pH progressively, the aggregation-inducing effect of BeSO4was promoted increasingly, and the profile of the initial velocity of the aggregation with respect to the salt concentration approached to that observed for the aggregation induced by La3+ion. This result demonstrates that the high activity of BeSO4to induce the aggregation of acidic phospholipid vesicles is attributed to the formation of trivalent complex cation, [Be3(OH)3]3+, due to the hydrolysis of Be2+in an aqueous solution.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.