Abstract
Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles . In this paper, we examined the kinetics of acoustic release of doxorubicin using stabilized and non-stabilized micelles. Kinetic models were used to regress release and re-encapsulation time constants for three different compounds, namely non-stabilized Pluronic ® P105 micelles, P105 micelles stabilized using an interpenetrating network of N,N-diethylacrylamide and micelles formed by PEO-b-poly(NIPAAm-co-HEMA-lactate n ). Results showed that the kinetic release constant ( k r ) depends on the micellar system under investigation. On the other hand, there is no statistically significant difference between re-encapsulation rate constants for stabilized and unstabilized micelles. We hypothesize that k r depends on the degree of cross-linking or stabilization.
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