Abstract
ALTHOUGH acetylsalicylic acid (ASA) has been in extensive clinical use since 1900, there is surprisingly little known with accuracy about the kinetics of absorption, metabolism, distribution and excretion of this drug in man and animals. Also, much of the present information has been indirectly estimated from the studies of the metabolite salicylic acid (SA). This has been a result of the lack of specific and sensitive methods for the determination of ASA in biological fluids. Further, while ASA has been shown to be present in the blood after an oral dose1–7, only the data of Leonards3 allow an assessment of the elimination half-life of ASA in man (17 min). The latter data were obtained utilizing a method which relies on measuring ASA as the difference between free and total salicylate, however. We therefore decided to investigate in more detail the pharmacokinetics of ASA in man.
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