Abstract
We studied the effects of oral medroxyprogesterone acetate (provera) administration on the kinetics of testosterone metabolism in normal young men. We investigated changes in the metabolic clearance rate, transport and metabolic rate constants, volumes of distribution, plasma levels, blood production rates and levels of binding to plasma proteins. In all subjects the plasma level and blood production rate for testosterone decreased during provera administration. When provera was administered for 5 days the metabolic clearance rate and volumes of distribution decreased. After 10 days of administration, the changes in the metabolic clearance rate were variable. In the 5 day studies, the levels of binding of testosterone to plasma proteins increased; they showed variable changes after 10 days.
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