Abstract
This paper presents a multivariable robust control structure for perfusion animal cell cultures. The control structure assumes a cascade form, where a linearizing feedback controller is used in the inner loop and linear controllers are used in the outer loops, to simultaneously control the cells concentration and the glucose concentration in the bioreactor. The growth rates needed by the linearizing controller are robustly estimated using sliding mode observers (SMO). Aside the effectiveness and the simplicity of the implementation and tuning, the proposed control scheme has the advantage that it does not require the knowledge of the process kinetics structure, which is generally difficult to identify.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
