Abstract
The permeation of testosterone analogs through silicone membranes was studied. The variation in the lipophilicity of testosterone molecules was accomplished by the addition or elimination of methyl group and the formation of ester. Furthermore, the effects of replacing one of the CH3 groups on the dimethylsiloxane unit in the silicone polymer chains by a polar CH2CH2CF3, group, which changes polymer characteristics and thus affects the membrane permeability, was investigated as well. It was found that potential which might prevent flocculation altogether. This can lead to caking. The lowest concentration effective in prevent ing coagulum formation should be used.Suspensions made from a fluid aluminum hydroxide concentration were easy to redisperse after six weeks of storage. The sedimentation volume was 0.64. Addition of 0.2% xanthan gum raised the sedimentation volume to a value of 1.0. There was no evidence of coagulum formation in this system.
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