Abstract
The rate of hydrolysis of p-chlorophenyl-2-furohydroxamic acid [4-Cl-C 6 -H 4 N(OH)-C(O)-C 4 H 3 O] has been studied over a wide range of acidities in hydrochloric, sulphuric and perchloric acids in 20% (v/v) dioxane-water at 55 °C. The kinetics has been analysed by Bunnett, Bunnett-Olsen and Cox-Yates excess acidity treatments. Solvent, salt and temperature effects has also been probed. The mechanism of acid-catalysed hydrolysis is postulated as involving two steps : a rapid protonation and a rate-determining A-2 nucleophilic attack by water.
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