Abstract
AbstractThe mechanism of the intermolecular hydroarylation of vinyl arenes (1) with 1,2‐dimethylindole (2) catalyzed by PtCl2 has been evaluated through a combination of kinetic analysis, deuterium labeling studies, and stereochemical analysis. The results of these and additional experiments are consistent with a mechanism for hydroarylation involving rapid and reversible complexation of vinyl arene to the catalytically inactive platinum mono(vinyl arene)complex trans‐PtCl2(H2C=CHAr)(solvent) to form the reactive platinum bis(vinyl arene) complex trans‐PtCl2(H2C=CHAr)2, which undergoes turnover‐limiting, outer‐sphere attack of indole. Rapid protodemetallation of the resulting platinum alkyl complex releases product and regenerates the equilibrating mixture of platinum π‐vinyl arene complexes.
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