Abstract
The kinetics of the electron transfer in sofosbuvir (Sofo) using N-bromosuccinimide (NBS) in aqueous medium has been studied spectrophotometrically over the (10–30) °C range, (0.1–0.5) mol dm−3 ionic strength, pH = 6.0–8.0 range over a range of NBS and Sofo concentrations. The rate of reaction was first order dependence on both [NBS] and [Sofo] and decreased with increasing [H+] over the range studied suggesting that the deprotonated form of sofosbuvir is more reactive than its conjugate acid. The hydrogen atom attached to the nitrogen atom of pyrimidine dione ring has a highly acidic character due to withdrawing effect of the adjacent two carbonyl groups and so the sofosbuvir acted as an acid. The rate decreased with increasing the ionic strength of the reaction mixture and supported that the reaction took place between two ions of different charges.
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