Abstract
Oxidation of inositol (INOS) by hexachloroplatinate(IV) complex (HCP) in perchlorate solutions in the presence of palladium(II) catalyst was studied spectrophotometrically. The reaction rate was very slow in the absence of the catalyst. The reaction exhibited a first order dependence on [HCP], and fractional-first order dependences with respect to [INOS], [H+] and [Pd(II)]. Increasing ionic strength and dielectric constant was found to increase the oxidation rate. A probable oxidation mechanism has been suggested and the rate-law expression has been derived. Both spectral and kinetic evidences revealed formation of a 1:1 intermediate complex between INOS and Pd(II) prior to the rate-controlling step. The final oxidation product of inositol was identified by both spectral and chemical analyses as the corresponding monoketone derivative, namely inosose. The activation parameters of the second order rate constant were evaluated and discussed.
Highlights
Anticancer platinum(IV) complexes have attracted many researchers in the last decades [1,2,3,4]
Oxidation of inositol was studied by different oxidants like alkaline potassium periodate [20], alkaline diperiodatocuprate(III) [21], alkalinepermanganate [22], V(V) in acid medium [23] and chromic acid [24]
This work aims to study the selectivity of inositol towards hexachloroplatinate(IV) complex (HCP) in acidic medium, to check the catalytic efficiency of Pd(II) catalyst and to elucidate a probable oxidation mechanism
Summary
Anticancer platinum(IV) complexes have attracted many researchers in the last decades [1,2,3,4]. Hexachloroplatinate(IV) complex is considered as one of the most important platinum(IV) complexes applicable to oxidize various organic and inorganic compounds in different media [2,3,4,5,6,7,8,9,10,11,12,13,14,15]. Inositol and some of its mono and polyphosphates function as the basis for a number of signaling and secondary messenger molecules [17, 18]. These are involved in insulin signal transduction, gene expression, breakdown of fats and reducing blood cholesterol [19]. Oxidation of inositol was studied by different oxidants like alkaline potassium periodate [20], alkaline diperiodatocuprate(III) [21], alkalinepermanganate [22], V(V) in acid medium [23] and chromic acid [24]
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