Abstract
Chloride substitution in the [Pt2(6NNqui)Cl4] bimetallic platinum(II) complex (6NNqui=N1,N6-bis(2-quinolinylmethyl)-1,6-hexanediamine) by thiourea, l-methionine, and glutathione have been studied at 310, 320, and 330K in water-DMF medium (1:1v/v). The ionic strength was 0.1M (Na+, ClO4−, Cl−, Tris buffer) and pH was 7.4 (0.05M Tris-HCl buffer). Addition of chlorides ([Cl−]=0.01M) prevented the complex hydrolysis. In case of the reaction with thiourea, the second-order rate constants for the first chloride substitution revealed unexpectedly low. This behavior has been discussed. Activation parameters (ΔH≠ and ΔS≠) confirmed associative mode of reactions. Cytotoxicity of the complex has been analyzed.
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