Abstract
The adsorption of the Ibuprofen (Ibu) drug on β-cyclodextrin (β-CD) grafted chitosan polymer was studied under different experimental conditions. The effect of Ibu concentration, mass of β-CD grafted chitosan polymer as adsorbent, contact time, temperature and pH were investigated. Three equilibrium models, Langmuier, Freundlich and Temkin isotherm models were analyzed to evaluate the adsorption isotherms. The adsorption isotherms were best fitted by Freundlich isotherm model, with correlation coefficient 0.9882, the intensity of adsorption parameters was lower than one and Freundlich adsorption isotherm constant value was more than one. High adsorption was found in acidic media pH 2, 27°C and 1 h adsorption time. In order to investigate the kinetic of the adsorption process four kinetic models were analyzed, pseudo first order kinetic model, pseudo second order kinetic model, the Elovich kinetic model and intraparticle diffusion kinetic model. Kinetic parameters include; binding strength constant, first order adsorption rate constant, intraparticle diffusion rate constant, adsorption half time, rate constant, equilibrium constant and adsorption capacities. Correlation coefficient for each kinetic equation was reported. The adsorption kinetics was best fitted by pseudo-first order kinetic equation, with correlation coefficient 0.9922. The rate determining step is well described by intraparticle diffusion process. The Intraparticle diffusion rate constant values ranging from 0.163 to 1.1441 mgg-1 min-1/2
Highlights
Cyclodextrins (CDs) are cyclic oligosaccharides of Glucopyranose
Results and Discussion β-CD grafted chitosan polymer was characterized by solubility measurements, FTIR, XRD and Scanning Electron Microscope (SEM)
In this study β-CD grafted chitosan polymer was successfully synthesized as confirmed by solubility, FTIR, XRD and SEM techniques
Summary
Cyclodextrins (CDs) are cyclic oligosaccharides of Glucopyranose. CDs may consist of 6 to 12 glucopyranose units connected to each other to from the ring. One of the most important properties of CDs is their ability to from inclusion compounds with various guest molecules, where the guest is embedded within the host non-polar cavity (Del Valle, 2003). The requirement for the inclusion is that the guest molecule must fit entirely, or at least partially, into the CD cavity to make the complex. Shape and polarity of the guest molecule relative to the CDs low polar inner cavity are critical parameters for the host-guest complexation (Singh et al, 2010; Al-Sou’od, 2006; Kawasaki et al, 2001)
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