Abstract
Abstract A kinetic study involving 4-hydroxycinnamic acid derivatives (HCAs) was performed in order to clarify the mechanism for free radical-scavenging and vitamin E-regenerating. The second-order rate constants of the radical-scavenging reaction (ks) observed for caffeic acid derivatives are larger than those for ferulic acid derivatives. The result may be explained by i) the lower oxidation potential coming from the existence of the more electron-donating hydroxy group comparing with methoxy group, and ii) the stabilization effect of the corresponding radicals produced in the radical-scavenging reaction through intramolecular hydrogen bonding. The radical-scavenging activity of HCAs in ethanol mainly occurs via the hydrogen atom transfer from the phenolic OH-protons. The pH dependence of ks for ferulic acid in the aqueous Triton X-100 micelle solutions suggests the importance of the phenolic OH proton on the radical-scavenging reaction. On the other hand, the pH dependence of ks for caffeic acid and chlorogenic acid suggests the occurence of intramolecular hydrogen bonding and an electron-transfer process in the radical-scavenging reaction.
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