Kinetic study on reactive extraction of clorprenaline enantiomers with a combined chiral selector

Abstract

ABSTRACTThis paper reports on the kinetic study on reactive extraction of clorprenaline (CPNL) enantiomers with isobutyl (d)-tartrate (DT) and boric acid (BA) as combined chiral selector in a Lewis cell, where exists an interfacial reaction involving three species: BA, DT, and CPNL enantiomers. The important factors that influence the kinetics of reactive extraction are investigated. Through multiple linear regression analysis of the experimental data, the order with respect to BA, CPNL, and DT of the interfacial reaction is 0.6, 0.8, and 0.8, respectively, and the total order of reaction is about 2.2. The forward rate constants have been calculated to be 2.476 × 10–4 L1.53/(mol1.2 s) for (R)-CPNL and 1.349 × 10–4 L1.53/(mol1.2 s) for (S)-CPNL.