Abstract
The mass transfer kinetics of bovine serum albumin on Cibacron blue F3GA cellulose affinity membranes has been investigated. It was found that the multi-plate (MP) and transport models successfully described experimental breakthrough curves obtained by single-step frontal analysis. The correlation between the two models was used to estimate the rate coefficients of mass transfer from experimental data. The flow rate was found to have little effect on the performance of affinity membrane separations. The improvement of the performance by increasing the thickness of the membranes was limited. The transport model was simplified by approximating the very sharp Langmuir isotherm determined by a rectangular isotherm and an analytical solution obtained although this was found to be unsuited to describe the experimental data.
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