Abstract
The distribution of intraperitoneally injected 51Cr-labeled peritoneal cells in syngeneic recipient mice was markedly altered by treatment with antimacrophage serum. The spleen-seeking segment of the peritoneal population was virtually eliminated by treatment of the cells in vitro with antimacrophage serum. Pretreatment of recipient mice with the same serum resulted in increased accumulation of labeled cells in the spleen and reduced migration of cells to the bone marrow. Injection of the recipients with antimacrophage serum at the time of cell introduction caused decreased recovery of labeled peritoneal cells from the spleen. Treatment of donors with antimacrophage serum resulted in nearly normal distribution patterns. Antithymocyte serum and normal rabbit serum did not effect the distribution of intraperitoneally injected labeled peritoneal cells. AMS was shown to be ineffective in promoting the survival of skin allografts when ALS activity was removed by absorption with lymphocytes.
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