Abstract
BackgroundTPN infusions are usually administered during a treatment period of 10–24 hours per day due to the metabolic capacity of the liver. During this time interval physicochemically stable TPN solution (emulsion) is needed for the treatment. The purpose of the present study was to examine how the kinetic stability features of ready-made total parenteral nutrition admixtures containing olive oil and soybean oil will change under the usage-modeling 24-hour application with and without overdose Ca2+.MethodsParticle size analysis and zeta potential measurements were carried out to evaluate the possible changes in the kinetic stability of the emulsions.ResultsOur results indicate that in two of the four mixtures bimodal droplet-size distribution figures were detected and appearance of fat particles over 5 μm can not be disclosed. The tendency for separation of large diameter droplets in the two types of oil-based emulsion systems was different. In case of soybean containing emulsion second peak of droplets appeared in the bottom of the container in contrast to the olive oil containing emulsions where the second peak appeared in the surface layer. Interestingly this phenomenon is independent of calcium-content.ConclusionsFrom therapeutic point the emulsions of the bigger droplets containing upper layer are safer because the potentially dangerous big droplets could remain in the infusion bag after the administration.
Highlights
Total parenteral nutrition (TPN) infusions are usually administered during a treatment period of 10–24 hours per day due to the metabolic capacity of the liver
Total parenteral nutrition admixtures Since over two decades it is well-known that good availability of nutrients can be reached by simultaneous administration of macronutrients
Should we concentrate to the intravenous nutrition, these solutions are basically composed of amino acids, glucose and fat emulsions they are called as all-in-one mixtures
Summary
TPN infusions are usually administered during a treatment period of 10–24 hours per day due to the metabolic capacity of the liver During this time interval physicochemically stable TPN solution (emulsion) is needed for the treatment. The olive oil consists of mainly MUFA that has a lot of beneficial properties, primarily the stability against lipid-peroxidation [4] This is important in case of storage because in the plastic (EVA) bags used for storage of TPNs peroxidation of lipids is much more pronounced than that in glass bottles [5]. Ca2+ in the emulsions [8] and the lipid-peroxidation can play a role in the aging processes of colloid systems like oil-containing TPNs, this property of olive oil can be of importance in case of kinetic/physical stability of all-in-one nutrient mixtures we did not study the details of aging process itself in this experiment
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