Abstract
Background: Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidanthaspoor solubility leads to poorbioavailability and limits its development. Fisetinnanocrystals were produced by nanoprecipitation technique and transformed into dry powder by lyophilisation. Objective: The aim of the study is to investigate the kinetic solubility of fisetinafter produced into nanocrystals. Methods: Fisetin nanocrystalswere prepared by nanoprecipitationwith different proportion of stabilizers and transformed into dry powder by lyophilization. In a period of 1 week, the kinetic solubility was determined using a shaker water bath at 37OC. Result: Showed fisetin nanocrystals were almost completely dissolved within 15 min in water and buffer pH 1,2. In contras, only 55% of fisetin raw material at the same condition. Conlusions: Lyophilizedfisetinnanocrystals could be re-dispersed completely in water, buffer pH 1,2 and the kinetic solubility in water increased to 420 ηg/ml.
Highlights
Flavonoids, e.g., fisetin, luteolin and kaemferol comprise a vast group of naturally occurring polyphenolic compounds, considered as active pharmaceutical ingredients (APIs), and present in daily consumed vegetables, fruits and products of that origin (Scholz and Keck, 2014., Chen et all,2014).Fisetin (FIS, 3,7,3',4'tetrahydroxyflavone, Fig 1) belongs to the flavonol subgroup of flavonoids found in 65 many vegetables and fruit and is especially rich in apples, strawberries, onions and mangoes (Seguin et all, 2013., Wang et all., 2016)
Replacing the pressure terms with solubilities, as activity coefficients are effectively set equal to the unity in the dilute solutions considered here, produces the so-called Gibbs–Kelvin relation. The aim of this studyis to assess of kinetic saturation solubilityoffisetinnanocrystal.The physicochemical properties of thefisetinnanocrystals and the nanocrystal powder have been investigated regarding crystallinity and kinetic solubility
Materials Fisetin (98%) raw material was purchased from Shaanxi Dideu Medichem Co
Summary
Flavonoids, e.g., fisetin, luteolin and kaemferol comprise a vast group of naturally occurring polyphenolic compounds, considered as active pharmaceutical ingredients (APIs), and present in daily consumed vegetables, fruits and products of that origin (Scholz and Keck, 2014., Chen et all,2014).Fisetin (FIS, 3,7,3',4'tetrahydroxyflavone, Fig 1) belongs to the flavonol subgroup of flavonoids found in 65 many vegetables and fruit and is especially rich in apples, strawberries, onions and mangoes (Seguin et all, 2013., Wang et all., 2016). It exhibits antioxidant, anti-inflammatory and anticarcinogenic activities. The aim of this studyis to assess of kinetic saturation solubilityoffisetinnanocrystal.The physicochemical properties of thefisetinnanocrystals and the nanocrystal powder have been investigated regarding crystallinity and kinetic solubility
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