Kinetic Resolution via the [2,3] Stevens Rearrangement of Epimeric Six-membered Ammonium Ylides: A New Entry to Enantio-enriched α-Amino Acid Derivatives

Abstract

The asymmetric [2,3] Stevens rearrangement of epimeric mixtures of N-allylic ammonium salts derived from (5R)-5-phenyl-1,4-oxazin-2-one is shown to proceed with efficient kinetic resolution to afford the unnatural α-aminoacid derivatives in high enantio-purities.