Kinetic resolution of mandelate esters via stereoselective acylation catalyzed by lipase PS-30

Peiran Chen,Wenhong Yang

doi:10.1016/j.tetlet.2014.02.095

Kinetic resolution of mandelate esters via stereoselective acylation catalyzed by lipase PS-30

Peiran Chen, Wenhong Yang

https://doi.org/10.1016/j.tetlet.2014.02.095

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Journal: Tetrahedron Letters	Publication Date: Mar 3, 2014
Citations: 13

Affiliation: Donghua University, Shanghai Institute of Organic Chemistry

#Lipase PS-30 #Mandelate Esters + Show 7 more

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Abstract

By using lipase PS-30 as catalyst, the kinetic resolution of a series of racemic mandelate esters has been achieved via stereoselective acylation. The value of kinetic enantiomeric ratio (E) reached up to 197.5. Substituent effect is briefly discussed.

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