Abstract
This study investigates the usage of electrohydrodynamic (EHD)-3D printing for the fabrication of bacterial cellulose (BC)/polycaprolactone (PCL) patches loaded with different antibiotics (amoxicillin (AMX), ampicillin (AMP), and kanamycin (KAN)) for transdermal delivery. The composite patches demonstrated facilitated drug loading and encapsulation efficiency of drugs along with extended drug release profiles. Release curves were also subjected to model fitting, and it was found that drug release was optimally adapted to the Higuchi square root model for each drug. They performed a time-dependent and diffusion-controlled release from the patches and followed Fick’s diffusion law by the Korsmeyer–Peppas energy law equation. Moreover, produced patches demonstrated excellent antimicrobial activity against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) strains, so they could be helpful in the treatment of chronic infectious lesions during wound closures. As different tests have confirmed, various types of antibiotics could be loaded and successfully released regardless of their types from produced BC/PCL patches. This study could breathe life into the production of antibiotic patches for local transdermal applications in wound dressing studies and improve the quality of life of patients.
Highlights
IntroductionProper wound management is essential to guard wounded areas from pathogens responsible for secondary infections
Antibiotic patches composed of bacterial cellulose (BC)/PCL, AMX, AMP, and KAN, were prepared by the EHD-3D printing method, resulting in aligned layer-on-layer stacked fibers
The release of AMX, AMP, and KAN antibiotics from BC/PCL dosage forms was shown at 14 days (336 h)
Summary
Proper wound management is essential to guard wounded areas from pathogens responsible for secondary infections. If germs rapidly multiply in a wound, and the infection spreads, it could cause a serious internal infection [1]. An internal infection can delay wound healing by extending the inflammatory stage while the immune system responds and clears the infection [2]. In this respect, antibiotic patches are an innovative approach, i.e., to deliver improved healthcare, reduce overall healthcare costs, increase drug effectiveness, and balance the toxicity of drugs involved in local wound
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