Abstract
Kinetic properties of dehydroascorbic acid (DHA) transport were studied in erythrocytes of beagle dogs at 1 and 12 months. DHA uptake was much faster in erythrocytes of dogs at 1 than 12 months. Young dogs showed much greater affinity for DHA than adult dogs and the rate of DHA uptake was not affected by glucose. It was due to the presence of fetal erythrocytes with high activity of Glut-1 glucose transporter in young dogs. In adult dogs, DHA uptake was slow and competitively inhibited by physiological concentrations of glucose. Glut-4 was identified as the carrier protein responsible for DHA uptake in erythrocytes of adult dogs. Glut-4 was hardly detectable in neonatal dogs, but increased to adult levels by 3 months as fetal erythrocytes were eliminated and switched to adult cells.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
