Kinetic parameters of respiration in rat permeabilized hepatocytes upon Са2+ in various concentrations in medium and prolonged Influence of taurine

V M Merlavsky,O V Ikkert,R D Ostapiv,V V Manko

doi:10.30970/sbi.0902.439

Abstract

Kinetic parameters of respiration in rat permeabilized hepatocytes upon Са2+ in various concentrations in medium and prolonged Influence of taurine

Highlights

Hepatocytes play a vital role in providing of the entire organism functioning, be cause they are involved in the processes of endogenous and exogenous compounds detoxication, blood proteins synthesis and secretion, choleresis, glucose and tempera ture homeostasis maintenance etc
Brown has revealed that the substrate oxi dation kinetics is modified during hibernation and it provides the metabolism regulation by mitochondria [3]
It is considered to maintenance of provide energy processes intensity at sufficient level during hibernation, preserve cell and mitochondria against damage and give a chance to turn into active state quickly

Summary

Introduction

Hepatocytes play a vital role in providing of the entire organism functioning, be cause they are involved in the processes of endogenous and exogenous compounds detoxication, blood proteins synthesis and secretion, choleresis, glucose and tempera ture homeostasis maintenance etc.Calcium cations have the unique properties and universal ability of diverse signals transduction on the cellular level. Hepatocytes play a vital role in providing of the entire organism functioning, be cause they are involved in the processes of endogenous and exogenous compounds detoxication, blood proteins synthesis and secretion, choleresis, glucose and tempera ture homeostasis maintenance etc. Increase in Са2+ concentration in the cytosol activates various cell processes in different tissues or organs (including liver). It may cause the ATP lack in the cytosol. Living cells need the balance between producing and using of ATP for homeostasis maintenance. It requires the effective coordination of the cytosolic ATP-dependent processes velocity with the mitochondrial oxidative phosphorylation in tensity [20]. Accumulation of Са2+ by mitochondria serves as a signal to intensify ATP pro ducing if necessary, and transduction of this signal is based on activation of the mito chondrial Са2+-sensitive enzymes: α-ketoglutarate dehydrogenase, isocitrate dehydro genase and pyruvate dehydrogenase [15]

Methods

Results

Conclusion