Kinetic distribution of Cu, Se, and Zn in mice during ascites tumor-bearing period

Abstract

The kinetic distribution of64Cu,75Se, and69mZn radioactive tracers were determined in tissues of mice bearing ascites tumors and healthy ones. The HPGe gamma-ray spectrometric detection system was used for radionuclide analysis in tissues which were sampled at various periods after tracer injection during ascitic tumor growth. Significantly different distribution of64Cu,75Se, and69mZn were found in colon, small intestine, and liver of tumor-bearing mice. There was a dcerease of75Se in ascites and blood of tumor-bearing mice. The64Cu and69mZn concentration varied significantly in kidneys, and a similar effect was observed in the spleen for64Cu, too. A distinct variation of tracer distribution is also found at different stages after treatment. The results are discussed within the context of a correlation between elemental concentration and tumor-growth.