Abstract
A new analytical method for determination of paracetamol is proposed. This method is based on a novel B-Z oscillating system, which involves a Tetraazamacrocyclic Complex [CuL](ClO4)2as catalyst and malic acid as the substrate. The ligand L in the complex is 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene. By perturbation mount of paracetamol on the B-Z system, there is a linear relationship between the changes in the oscillation amplitude and the logarithm of paracetamol concentration in the range 5×10-7to 2×10-4M, with a correlation coefficient of 0.99743. The effects of influential variables, such as the concentration of reaction components, temperature and on the determinations were studied. The probable mechanism involving the perturbation of paracetamol on the oscillating chemical system was also discussed.
Highlights
Chemical oscillating reaction is one of a class of reactions that serve as a classical example of non-equilibrium thermodynamic, showing periodic changes in some intermediates over time[1]
H2O2–NaSCN–CuSO4 system is usually accomplished by using a continuous flow stirred-tank reactor (CSTR)
A first 20 minutes, the profile of the [CuL](ClO4)2-catalyed system is that it has consistent waveforms, with approximately constant oscillation period and constant amplitude, which may favor for determination of analytes by their perturbation effect on amplitude
Summary
Chemical oscillating reaction is one of a class of reactions that serve as a classical example of non-equilibrium thermodynamic, showing periodic changes in some intermediates over time[1]. Like Briggs-Rauscher (BR) reaction[3,4,5,6], Bray-Liebhafsky (BL) reaction[7,8,9,10,11,12] and H2O2–NaSCN–CuSO4 system[13,14,15] have been used as matrixes for analytical purpose. Compared with the above methods, this methodology uses very simple instruments and common, inexpensive reagents, and that it has higher sensitivity and reproducibility. This method suggested by our group has been already applied to determine to pyrogallol[30], catechol[31], alizarin red S32 and calcium pantothenate[33]. It can be seen that the linear range of our method is from 5×10-7 to 2×10-4 M, which is different from above data
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