Abstract
Chromatin structure is dynamically organized by chromatin remodelers, motor protein complexes which move and remove nucleosomes. The regulation of remodeler action has recently been proposed to underlie a kinetic proofreading scheme which combines the recognition of histone-tail states and the ATP-dependent loosening of DNA around nucleosomes. Members of the ISWI-family of remodelers additionally recognize linker length between nucleosomes. Here, we show that the additional proofreading step involving linker length alone is sufficient to promote the formation of regular arrays of nucleosomes. ATP-dependent remodeling by bidirectional motors is shown to reinforce positioning as compared to statistical positioning. DOI: 10.1103/PhysRevLett.109.118103
Highlights
Chromatin structure is dynamically organized by chromatin remodelers, motor protein complexes which move and remove nucleosomes
We show that the additional proofreading step involving linker length alone is sufficient to promote the formation of regular arrays of nucleosomes
Submit your manuscript to BioMed Central and take full advantage of: 2Interdisciplinary Research Institute, Université des Sciences et des Technologies de Lille (USTL), CNRS USR 3078,50, Avenue Halley, 59568 Villeneuve d’Ascq, France Full list of author information is available at the end of the article
Summary
Chromatin structure is dynamically organized by chromatin remodelers, motor protein complexes which move and remove nucleosomes. Kinetic control of nucleosome displacement by ISWI/ACF chromatin remodelers
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